A MAN sustained serious injuries following a three vehicle road smash on the B1249, three miles south of Langtoft.
A 19 year old girl was also airlifted to hospital in the wake of the incident at around 9.55am on Tuesday.
Police said that a black Mini Cooper S, a grey VW Golf and a Fiat Ducato van were involved.
The driver of the Mini Cooper, a 20 year old man from Nottingham, was taken to Hull Royal Infirmary with serious injuries.
He remained in hospital as the Driffield Times and Post went to press.
A 19 year old girl, who was a passenger in the Mini Cooper was airlifted to James Cook hospital in Middlesbrough.
She was treated for what were believed to be non life threatening injuries.
The driver of the VW Golf, a 40 year old man from Tibthorpe, was not injured.
The driver of the Ducato van, a 33-year-old man from Ravenscar, was also not injured.
Police closed the road at the roundabout at Langtoft for several hours and diverted traffic towards Kilham.
Anyone who may have witnessed the collision is asked to call Humberside Police tel 101 quoting log 160 of 27 November 2012.